The various versions of the scientific method are the best tools that we have in understanding how the material world works. In its ideal practice it combines rational thought with the necessity of acquiring empirical evidence. This underpins a self corrective methodology that is evidence driven.
Since we are part of the material world its utility in helping us navigate the challenges of our world provides for explanations that are beneficial and pragmatic on a go forward basis.
The second question has more to do with the level of uncertainty we as individuals are willing to live with. This varies subjectively.
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